Hormones and HRT
HRT risks & benefits
Worried about HRT risks? Unclear about the benefits? We answer your questions and provide expert advice.
Everything you need to know about Ovestin (0.1% Estriol cream)
Everything you need to know about Ovestin (0.1% Estriol cream)
Ovestin is a low-dose vaginal oestrogen cream containing estriol, a form of oestrogen that helps restore the vaginal tissues and improve symptoms of vaginal atrophy, dryness, and irritation.
In 2024, Ovestin was rebranded by the manufacturer and is now called 0.1% Estriol Cream. Despite the name change, the formulation remains the same, providing the same benefits for vaginal and urinary symptoms of menopause.
Medically reviewed by Dr. Liz Andrew
BMS Accredited Doctor
Reviewed: 18/03/2025 Published: 20/03/2025.png)
The basics
Key Information About Ovestin (0.1% Estriol Cream)
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Benefits of Ovestin (0.1% Estriol Cream)
- Restores vaginal moisture – reducing dryness, irritation, and discomfort
- Supports bladder health – reducing urinary urgency, frequency, and infections
- Helps with mild prolapse symptoms – by improving vaginal tissue strength
- Can be used long-term – safe for extended use without major systemic effects
- Easy to apply – simple at-home use
Side effects of Ovestin (0.1% Estriol Cream)
Most women tolerate Ovestin cream well, as it works locally with minimal absorption into the bloodstream. However, like all medications, it can cause side effects, particularly in the first few weeks of use.
Common Side Effects (Usually Settle with Time):
- Mild vaginal irritation (burning, itching, or discharge)
- Breast tenderness
- Headaches
- Bloating or mild stomach discomfort
- Skin irritation if applied externally
Most side effects settle within a few weeks as your body adjusts. If symptoms persist or worsen, speak to your doctor about adjusting your dose or trying an alternative treatment.
Learn more about your treatment options
Book a complementary discovery call with our patient expert Jane James. Jane can help you by:
- Explaining the clinical pathway and how oestrogen patches can be prescribed through Menopause Care
- Offering guidance as to whether you may benefit from hormone replacement therapy (HRT)
- Share personal insight and other patient experiences of oestrogen treatment (non-clinical advice)
- Offering compassionate support and a safe, confidential space to openly discuss your concerns
4 tips to help you
How and where to apply Ovestin cream?
- 1
Insert using the applicator
A small amount is inserted into the vagina before bed, usually daily for the first few weeks, then reduced to twice a week for maintenance.
- 2
Can also be used externally
A pea-sized amount can be applied to the vaginal opening or vulva for additional relief.
- 3
Consistency is key
It may take a few weeks to see full benefits.
- 4
Wash hands before and after use
To prevent irritation or transfer.
Our doctors provide holistic care for all menopause symptoms
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