Everything you need to know about Estradot

Estradot is a form of oestrogen replacement therapy used as part of Hormone Replacement Therapy (HRT). It is a transdermal patch, meaning it delivers oestrogen through the skin rather than orally.

If you are considering Estradot as part of your HRT plan, here is what you need to know about how to use it, its benefits, and possible side effects.

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Medically reviewed by Dr. Liz Andrew

BMS Accredited Doctor

iconReviewed: 19/02/2025 Published: 21/02/2025
The basics

Key information about Estradot

Benefits of Estradot

Replacing oestrogen with Estradot can bring many benefits, and have an impact on all 40 symptoms of menopause.

  • Supports bone health - reduces the risk of osteoporosis
  • Provides a steady release of oestrogen - helping to maintain stable hormone levels
  • Bypasses digestion - making it a gentler option for those who experience stomach issues with oral HRT
  • Lower risk of blood clots - compared to oral oestrogen
Simple and flexible care for your symptoms

Learn more about our personalised plans

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How and where to apply Estradot?

In this short clip menopause expert Dr Eloise Elphinstone explains her top tips when using Estradot

Learn more about your treatment options

Book a complementary discovery call with our patient expert Jane James. Jane can help you by:

  • Explaining the clinical pathway and how oestrogen patches can be prescribed through Menopause Care
  • Offering guidance as to whether you may benefit from hormone replacement therapy (HRT)
  • Share personal insight and other patient experiences of oestrogen treatment (non-clinical advice)
  • Offering compassionate support and a safe, confidential space to openly discuss your concerns

Estradot side effects

Common side effects can include:

  • Skin irritation on the site which the patch is applied
  • Breast tenderness or pain
  • Bloating
  • Abdominal pain
  • Headaches
  • Mood changes

Estradot dosages explained

Everything you need to know about Estradot dosages
25mcg patch
Dosage level.

Provides 25mcg of estradiol. This is considered a low dose.

How often should you change your patch?

Every 3-4 days

50mcg patch
Dosage level

Provides 50mcg of estradiol. This is considered a moderate dose.

How often should you change your patch?

Every 3-4 days

75mcg patch
Dosage level

Provides 75mcg of estradiol. This is considered a moderate dose.

How often should you change your patch?

Every 3-4 days

100mcg patch
Dosage level

Provides 100mcg of estradiol. Considered a high dose

How often should you change your patch?

Every 3-4 days

Additional information

As this is a higher dose of oestrogen, higher doses of progesterone are needed, if you still have a womb.

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Dr. Liz Andrew
Your dosage level of Estradot can vary depending on the individual. This should be explained clearly by your doctor before starting medication and also throughout your treatment if you are making any adjustments.
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Estradot explained

Dr. Laura Cawley and Dr. Liz Andrew explain Estradot on one of our latest webinars all about HRT and testosterone products. You can watch the fully recorded webinar on YouTube.