Everything you need to know about Lenzetto

Lenzetto is a form of oestrogen replacement therapy used as part of Hormone Replacement Therapy (HRT). It is a transdermal spray, meaning it delivers oestrogen through the skin, rather than being taken orally.

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Medically reviewed by Dr. Liz Andrew

BMS Accredited Doctor

iconReviewed: 24/02/2025 Published: 25/02/2025
The basics

Key information about Lenzetto

Benefits of Lenzetto

Replacing oestrogen with Lenzetto can bring many benefits, and have an impact on all 40 symptoms of menopause.

  • Relieves menopause symptoms
  • Supports bone health - reduces the risk of osteoporosis
  • Bypasses digestion - making it a gentler option for those who experience stomach issues with oral HRT
  • Lower risk of blood clots - compared to oral oestrogen
  • Easy & quick application - Lenzetto spray dries faster than oestrogen gels. There is less skin residue like oestrogen gels and it is good for women who dislike patches or gels.
  • Discreet & portable - it is a small spray bottle.
Simple and flexible care for your symptoms

Learn more about our personalised plans

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How and where to use Lenzetto?

Menopause Expert Dr Eloise Elphinstone explains her top tips when using Lenzetto Spray

Learn more about your treatment options

Book a complementary discovery call with our patient expert Jane James. Jane can help you by:

  • Explaining the clinical pathway and how oestrogen patches can be prescribed through Menopause Care
  • Offering guidance as to whether you may benefit from hormone replacement therapy (HRT)
  • Share personal insight and other patient experiences of oestrogen treatment (non-clinical advice)
  • Offering compassionate support and a safe, confidential space to openly discuss your concerns

Side effects of Lenzetto

Common side effects of Lenzetto can include:

  • Breast tenderness
  • Headaches
  • Nausea
  • Bloating
  • Changes in mood
  • Skin irritation at the application site

Less Common Side Effects of Lenzetto are:

  • Dizziness
  • Fluid retention
  • Leg cramps
  • Changes in libido

Lenzetto dosages explained

Everything you need to know about Lenzetto dosages
1 spray of Lenzetto
Dosage level

Provides 1.53mg of estradiol. This is considered a very low dose.

Application frequency

Applied daily

2 sprays of Lenzetto
Dosage level

Provides 3.06mg of estradiol. This is considered a low dose.

Application frequency

Applied daily

3 sprays of Lenzetto
Dosage level

Provides 4.59mg of estradiol. This is considered a standard dose.

Application frequency

Applied daily

4-5 sprays of Lenzetto
Dosage level

Provides 6.12 to 7.65mg estradiol. This is considered a moderate dose.

Application frequency

Applied daily

6 sprays of Lenzetto
Dosage level

Provides 9.18mg estradiol. This is considered a high dose.

Application frequency

Applied daily

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Dr. Liz Andrew
Your dosage level of Lenzetto can vary depending on the individual. This should be explained clearly by your doctor before starting medication and also throughout your treatment if you are making any adjustments.
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Lenzetto explained

Dr. Liz Andrew explains Lenzetto on one of our latest webinars all about HRT and testosterone products. You can watch the fully recorded webinar on YouTube.