Everything you need to know about Oestrogel

Learn more about Oestrogel, and whether it’s something you might want to try as part of your HRT plan. Oestrogel is a form of oestrogen replacement therapy. It is a transdermal gel, meaning it is absorbed through the skin rather than taken as a pill.

If you are considering Oestrogel as part of your HRT plan, here is what you need to know about how to use it, its benefits, and possible side effects.

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Medically reviewed by Dr. Liz Andrew

BMS Accredited Doctor

iconReviewed: 19/02/2025 Published: 20/02/2025
The basics

Key information about Oestrogel

Oestrogel is a transdermal oestrogen gel used in hormone replacement therapy. It contains estradiol, a form of oestrogen identical to the hormone naturally produced by the body.

Unlike tablets, Oestrogel is applied directly to the skin, where it is absorbed into the bloodstream. This avoids the digestive system and liver, helping maintain more stable hormone levels.


Oestrogen works by:

  • Replacing declining oestrogen levels during menopause
  • Regulating body temperature (reducing hot flushes)
  • Supporting mood, sleep, and cognitive function
  • Helping maintain bone density

This delivery method is often preferred for women who want a flexible, lower-risk HRT option.

Oestrogel is a safe and effective form of HRT for many women. Because it is absorbed through the skin, directly into the bloodstream and bypasses the liver, reducing some of the risks associated with oral oestrogen.

However, as with all HRT, the benefits and risks should be discussed with a doctor to ensure it is the right option for you and these are highly personalised to your own medical history.

If you have a womb, then your Oestrogel should be prescribed alongside a progesterone. This protects the lining of the womb.

Oestrogel is body identical. It contains estradiol, which has the same chemical structure as the oestrogen naturally produced by the body. This makes it a well-tolerated option for many women.

There is no evidence that Oestrogel causes weight gain. However, menopause itself can cause changes in metabolism, fat distribution, and muscle mass, which may affect weight.

Some women notice temporary bloating or fluid retention when starting HRT, but this usually settles within a few months. Maintaining a balanced diet and regular exercise can help manage any changes. If you have concerns, speak with your doctor about adjusting your treatment.

Oestrogel is suitable for women experiencing:

  • Perimenopause symptoms
  • Menopause-related hormonal decline
  • Surgical menopause
  • Early menopause

It is particularly beneficial for:

  • Women sensitive to oral medications
  • Those wanting flexible dosage control
  • Patients seeking a transdermal HRT option

At Menopause Care, every treatment plan is personalised following a clinical consultation to ensure safety and effectiveness.

You should see symptom reductions within the first 3 months. If you experience no improvements at all, your doctor is likely to check you are absorbing oestrogen with a blood test. If you experience some improvements, but not complete symptom relief your doctor may adjust your dose.

1 pump measure of oestrogel contains 25mcg oestradiol. This is the same amount of oestrogen as delivered through as 25mcg patch.

Dosage varies depending on symptoms, age, and medical history. Your prescription should specify how many pumps you need to use each day. Typically women will start on 1-2 pumps per day, and adjust up with their doctor at their review appointments.

  • 1 pump = 25mcg estradiol
  • 2 pump = 50mcg estradiol
  • 3 pump = 75mcg estradiol
  • 4 pump = 100mcg estradiol

Low-dose Oestrogel is often recommended for early menopause or mild symptoms, while higher doses may be used for more severe cases.

With Menopause Care, your dosage is regularly reviewed and adjusted to deliver optimal results.

  • Oestrogel should be applied to clean, dry, unbroken skin (avoid breasts, genitals, face, or irritated areas).
  • Remove the cap from the canister.
  • Remove the stopper from the spout of the Oestrogel
  • Press the plunger down a few times - initially nothing will come out but then gel will start to come out
  • Don’t use the first dose of gel from your Pump Pack as this will likely not be a full dose. Discard this does
  • Press the pump again and this can be used as the first full dose.
  • A bottle of Oestrogel contains 64 metered doses.

More information on the packaging can be found here: https://www.oestrogel.co.uk

We would typically advise not to get the area in which the gel has been applied for at least 1 hour after the gel has been applied. This is to ensure that you have given the gel enough time to absorb, and you see the most benefit you can for this treatment.

Yes, all our expert clinicians can prescribe Oestrogel. If you book into a consultation your doctor will review your symptoms and medical history, and talk through your options. Whilst many women do start Oestrogel through our service, the final prescription decision will be with the prescribing clinician. We can not guarantee any prescriptions.

Benefits of Oestrogel

Oestrogel is widely used due to its effectiveness and adaptability, having an impact on all 40 symptoms of menopause.

Key benefits of oestrogel:

  • Effective Symptom Relief: Targets hot flushes, night sweats, and vaginal dryness.
  • Restored Sleep & Mood: Helps stabilize hormone fluctuations to improve sleep quality and reduce anxiety.
  • Enhanced Safety Profile: Carries a lower risk of blood clots compared to oral HRT.
  • Bone & Heart Support: Reduces the long-term risk of osteoporosis.
  • Stable Hormone Delivery: Provides a steady release of oestrogen for more consistent symptom control.
  • Gentle on the System: Bypasses the digestive tract, making it ideal for those with sensitive stomachs.
  • Tailored to You: Offers flexible dosing and better tolerability for those sensitive to synthetic hormones.
  • Simple & Non-Invasive: Easy to apply as part of your daily routine.

You should expect to see benefits to your symptoms within the first 3 months. If you experience some improvements, but not significant reductions in your symptoms, your doctor will speak to you about adjusting the dose at your 3 month review.

If you have not experienced any improvements to your symptoms after 3 months then there may be an issue with how you absorb the oestrogen in the product. Your doctor may want to check your oestrogen levels with a blood test.

If Oestrogel isn’t suitable, other options include:

  • Oestrogen patches
  • Oral HRT tablets
  • Oestrogen sprays
  • Bioidentical hormone therapy

Each has its pros and cons, and the best choice depends on individual needs.

Simple and flexible care for your symptoms

Learn more about our personalised plans

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How and where to apply oestrogel correctly

In this short clip menopause expert Dr Eloise Elphinstone explains her top tips when using Oestrogel

Apply one metered dose to each area e.g. if you use 2 doses, apply one dose to one inner thigh and another to an outer arm.

It is important not to apply gel to these areas

Be patient, and use the time to complete another simple task, like brushing your teeth. Just make sure to wash your hands thoroughly during this time.

  • Wash hands after use. Do not apply anything else to the skin for at least 2 hours after application
  • Do not apply to breasts or face.
  • Rotate application areas daily.

Learn more about your treatment options

Book a complementary discovery call with our patient expert Jane James. Jane can help you by:

  • Explaining the clinical pathway and how oestrogen patches can be prescribed through Menopause Care
  • Offering guidance as to whether you may benefit from hormone replacement therapy (HRT)
  • Share personal insight and other patient experiences of oestrogen treatment (non-clinical advice)
  • Offering compassionate support and a safe, confidential space to openly discuss your concerns

Side effects of Oestrogel

Common side effects can include:

  • Breast tenderness or pain
  • Bloating
  • Abdominal pain
  • Mild headaches
  • Mood changes
  • Skin irritation at application site

Less common risks:

  • Blood clots (lower risk than oral HRT)
  • Hormonal fluctuations
  • Irregular bleeding (especially early in treatment)

Many women will experience some side effects in their first few weeks of taking HRT - as your body adjusts to having different hormone levels. Side effects often settle in the first few weeks, and should have resolved fully by your 3 month review with your clinician.

If your side effects are impacting your quality of life, or they have not settled at three months, please speak to a doctor. If your side effects are severe, or you are concerned, you should speak to a doctor.

Yes, you can try alternative transdermal forms of oestrogen (patch or spray) or you could try oral progesterone.

  • Women with a history of breast cancer, blood clots, stroke, untreated high blood pressure, or severe liver disease.
  • Those who have unexplained vaginal bleeding should consult a doctor before use.

At Menopause Care, we ensure all patients receive medically supervised treatment aligned with UK guidelines.

play

Oestrogel explained

Dr. Laura Cawley and Dr. Liz Andrew explain Oestrogel on one of our latest webinars all about HRT and testosterone products. You can watch the fully recorded webinar on YouTube.

Oestrogel vs other HRT options

Choosing the right HRT depends on your lifestyle and medical profile.
Oestrogel vs tablets
Lower risk of clotting

More stable hormone levels

Avoids liver metabolism

Oestrogel vs patches
More flexible dosing

No adhesive irritation

Easier to adjust daily

Oestrogel vs sprays
Similar absorption

Gel allows broader application area

At Menopause Care, we help you compare options and choose the most suitable treatment for you..
Frequently asked questions

Everything you want to know about Oestrogel

No, Oestrogel is a prescription-only medication. This ensures that a healthcare professional can assess your medical history and confirm that it is an appropriate and safe option for you. At Menopause Care, our specialists provide comprehensive consultations to help determine if Oestrogel fits your clinical needs.

Many women find transdermal gel to be a preferable option. Because it is absorbed through the skin, it bypasses the digestive system and the liver, which may lead to a lower risk of blood clots compared to oral tablets. It can also help maintain more stable hormone levels for many individuals.


It is generally recommended to apply the gel to clean, dry skin on the outer arms, shoulders, or inner thighs. We advise avoiding the breast area or the face. Once applied, allowing a few minutes for the gel to dry before dressing can help ensure optimal absorption.

While many women tolerate Oestrogel well, some may experience mild, temporary symptoms such as breast tenderness, occasional headaches, or slight skin irritation. These often settle as your body adjusts, but our clinicians are always available to help review your dosage if needed.

While some women may notice a reduction in symptoms like hot flushes within the first few weeks, it can often take up to three months to experience the full benefits. This period allows your hormone levels to stabilize and for your specialist to ensure the treatment is working effectively for you.

For many women, Oestrogel can be an effective and safe option for long-term symptom management and bone health support. When monitored regularly by a specialist as part of an evidence-based care plan, it may provide ongoing relief and long-term health benefits.

There are various delivery methods available if a gel is not the right fit for your lifestyle. Alternatives may include transdermal patches, sprays, or oral options. During your consultation, we can explore these alternatives to find the most suitable approach for your symptoms.