Oestrogen gel

Oestrogen gel is an increasingly popular form of HRT and works by being applied to the skin and being gradually absorbed into your body. It can be started at low doses and increased as needed, giving the patient some flexibility.

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Medically reviewed by Dr. Liz Andrew

BMS Accredited Menopause Doctor

iconReviewed: 19/02/2025 Published: 21/02/2025

The Basics of Oestrogen Gel

Oestrogen gel is an increasingly popular form of HRT and works by being applied to the skin and being gradually absorbed into your body. It can be started at low doses and increased as needed, giving the patient some flexibility.

Gels are applied daily, usually in the morning, and allowed to dry fully before dressing. You need to wait at least an hour after application before bathing or swimming.

Like patches, oestrogen gels do not increase your risk of blood clots. If you still have a womb, you have to use these forms of oestrogen replacement in combination with progesterone.

What are the differences between the different Oestrogen gel brands?

Oestrogel is a body identical oestrogen product containing estradiol (which is derived from plants) and delivers a metered dose of oestrogen from a pump.

Easy to use and gentle on the skin, oestrogel is clear and colourless. Your prescribed dose of the gel is applied to the outer upper arms, shoulders or inner thighs every morning and allowed to dry. Each pump contains 64 doses.

Sandrena Gel is similar to oestrogel but comes as sachets in two different strengths so you can choose your dose. There is less quantity of gel for the same dose compared to oestrogel so it can be more practical in higher doses.

It is applied daily to clean, dry skin on the upper outer arms or the inner thighs. It dries within a few minutes, and you must not wash the area where you applied the gel for at least one hour

Learn more about your treatment options

Book a complementary discovery call with our patient expert Jane James. Jane can help you by:

  • Explaining the clinical pathway and how oestrogen patches can be prescribed through Menopause Care
  • Offering guidance as to whether you may benefit from hormone replacement therapy (HRT)
  • Share personal insight and other patient experiences of oestrogen treatment (non-clinical advice)
  • Offering compassionate support and a safe, confidential space to openly discuss your concerns
FAQs

Key information about Oestrogen gel

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