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Signs HRT is not working
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Everything you need to know about Vagifem pessaries
Everything you need to know about Vagifem pessaries
Vagifem is a local vaginal oestrogen treatment that comes in the form of a pessary (tablet) inserted directly into the vagina. It contains estradiol, a form of oestrogen that helps restore the vaginal tissues and improve symptoms of vaginal atrophy, dryness, and irritation.
Medically reviewed by Dr. Liz Andrew
BMS Accredited Doctor
Reviewed: 14/03/2025 Published: 20/03/2025
The basics
Key Information About Vagifem (10mcg Estradiol Pessaries)
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Benefits of Vagifem
- Restores vaginal moisture – reducing dryness, irritation, and discomfort
- Supports bladder health – reducing urinary urgency, frequency, and infections
- Helps with mild prolapse symptoms – by improving vaginal tissue strength
- Can be used long-term – safe for extended use without major systemic effects
- Easy to apply – simple at-home use with a pre-filled applicator
Vagifem side effects
Most women tolerate Vagifem well, as it works locally with minimal absorption into the bloodstream. However, like all medications, it can cause side effects, particularly in the first few weeks of use.
Common Side Effects (Usually Settle with Time):
- Mild vaginal irritation (burning, itching, or discharge)
- Bloating or mild stomach discomfort
- Spotting or light bleeding (usually in the first few months)
Most side effects settle within a few weeks as your body adjusts. If symptoms persist or worsen, speak to your doctor about adjusting your dose or trying an alternative treatment.
Learn more about your treatment options
Book a complementary discovery call with our patient expert Jane James. Jane can help you by:
- Explaining the clinical pathway and how oestrogen patches can be prescribed through Menopause Care
- Offering guidance as to whether you may benefit from hormone replacement therapy (HRT)
- Share personal insight and other patient experiences of oestrogen treatment (non-clinical advice)
- Offering compassionate support and a safe, confidential space to openly discuss your concerns
4 tips to help you
How to use Vagifem
- 1
Insert using the applicator
One pessary is inserted into the vagina, usually daily for the first two weeks, then reduced to twice a week for maintenance
- 2
Consistency is key
It may take a few weeks to feel the difference
- 3
Wash hands before and after use
To prevent irritation or transfer
- 4
For vaginal use only
The pessary should never be swallowed
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